LMRT 9/23/18 LMRT 9/23/18

Harnessing Protease Activity to Improve Cancer Care

J.S. Dudani, A.D. Warren, S.N. Bhatia.
Annu. Rev. Cancer Biol. 2, (2018).

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A Plasmodium berghei sporozoite-based vaccination platform against human malaria

A. M. Mendes, Machado, M., alves-Rosa, Nç, Reuling, I. J., Foquet, L., Marques, áudia, Salman, A. M., Yang, A. S. P., Moser, K. A., Dwivedi, A., Hermsen, C. C., nez-Díaz, éné, Viera, S., Santos, J. M., Albuquerque, ês, Bhatia, S. N., Bial, J., Angulo-Barturen, ñigo, Silva, J. C., Leroux-Roels, G., Janse, C. J., Khan, S. M., Mota, M. M., Sauerwein, R. W., and Prudêncio, M.
npj Vaccines, vol. 3, 2018.

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iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer

J. H. Lo†, Hao, L. †, Muzumdar, M. D., Raghavan, S., Kwon, E. J., Pulver, E. M., Hsu, F., Aguirre, A. J., Wolpin, B. M., Fuchs, C. S., Hahn, W. C., Jacks, T., and Bhatia, S. N.
Molecular Cancer Therapeutics, vol. 17, no. 11, pp. 2377-2388, 2018.

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Classification of prostate cancer using a protease activity nanosensor library

J. S. Dudani, Ibrahim, M., Kirkpatrick, J., Warren, A. D., and Bhatia, S. N.
Proc Natl Acad Sci U S A, vol. 115, no. 36, pp. 8954-8959, 2018.

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Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

S. R. Viswanathan, Nogueira, M. F., Buss, C. G., Krill-Burger, J. M., Wawer, M. J., Malolepsza, E., Berger, A. C., Choi, P. S., Shih, J., Taylor, A. M., Tanenbaum, B., Pedamallu, C. Sekhar, Cherniack, A. D., Tamayo, P., Strathdee, C. A., Lage, K., Carr, S. A., Schenone, M., Bhatia, S. N., Vazquez, F., Tsherniak, A., Hahn, W. C., and Meyerson, M.
Nature Genetics, vol. 50, no. 7, pp. 937 - 943, 2018.

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A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Kisalu, N.K., Idris, A.H., Weidle, C., Flores-Garcia, Y., Flynn, B.J., Sack, B.K., Murphy, Schön A., Freire, E., Francica, J.R., Miller, A.B., Gregory, J., March, S., Liao, H.X., Haynes, B.F., Wiehe, K., Trama, A.M., Saunders, K.O., Gladden, M.A., Monroe, A., Bonsignori, M., Kanekiyo, M., Wheatley, A.K., McDermott, A.B., Farney, S.K., Chuang, G.Y., Zhang, B., Kc, N., Chakravarty, S., Kwong, P.D., Sinnis, P., Bhatia, S.N., Kappe, S.H.I., Sim, B.K.L., Hoffman, S.L., Zavala, F., Pancera, M., and Seder, R.A.
Nature Medicine (2018)

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In vitro culture, drug sensitivity, and transcriptome of plasmodium vivax hypnozoites

N. Gural, L. Mancio-Silva, A.B. Miller, A. Galstian, V.L. Butty, S.S. Levine, R. Patrapuvich, S.P. Desai, S.A. Mikolajczak, S.H.I. Kappe, H.E. Fleming, S. March, J. Sattabongkot, and S.N. Bhatia
Cell Host & Microbe (2018)

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Personalized RNA-medicine for pancreatic cancer

M. - E. Gilles, Hao, L., Huang, L., Rupaimoole, R., Lopez-Casas, P. P., Pulver, E., Jeong, J. Cheol, Muthuswamy, S. K., Hidalgo, M., Bhatia, S. N., and Slack, F. J.
Clinical Cancer Research, vol. 24, no. 7, pp. 1734-1747, 2018.

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Engineered Livers for Infectious Diseases

N. Gural, Mancio-Silva, L., He, J., and Bhatia, S. N.
Cellular and Molecular Gastroenterology and Hepatology (2018)

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A robust cell culture system supporting the complete life cycle of hepatitis B virus

E. Michailidis, Pabon, J., Xiang, K., Park, P., Ramanan, V., Hoffmann, H. - H., Schneider, W. M., Bhatia, S. N., de Jong, Y. P., Shlomai, A., and Rice, C. M., “A robust cell culture system supporting the complete life cycle of hepatitis B virus”, Scientific Reports, vol. 7, no. 1, 2017.

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Engineering synthetic breath biomarkers for respiratory disease

L.W. Chan, M.N. Anahtar, T.-H. Ong, K.E. Hern, R.R. Kunz, and S.N. Bhatia
Nature Nanotechnology (2020)

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Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas

Y. Ren, Sagers, J. E., Landegger, L. D., Bhatia, S. N., and Stankovic, K. M., “Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas”, Scientific Reports, vol. 7, no. 1, 2017.

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Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

L. T. Geller†, Barzily-Rokni, M. †, Danino, T., Jonas, O. H., Shental, N., Nejman, D., Gavert, N., Zwang, Y., Cooper, Z. A., Shee, K., Thaiss, C. A., Reuben, A., Livny, J., Avraham, R., Frederick, D. T., Ligorio, M., Chatman, K., Johnston, S. E., Mosher, C. M., Brandis, A., Fuks, G., Gurbatri, C., Gopalakrishnan, V., Kim, M., Hurd, M. W., Katz, M., Fleming, J., Maitra, A., Smith, D. A., Skalak, M., Bu, J., Michaud, M., Trauger, S. A., Barshack, I., Golan, T., Sandbank, J., Flaherty, K. T., Mandinova, A., Garrett, W. S., Thayer, S. P., Ferrone, C. R., Huttenhower, C., Bhatia, S. N., Gevers, D., Wargo, J. A., Golub, T. R., and Straussman, R.
Science (2017)

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LMRT 10/1/16 LMRT 10/1/16

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

N. Kato†, Comer, E. †, Sakata-Kato, T., Sharma, A., Sharma, M., Maetani, M., Bastien, J., Brancucci, N. M., Bittker, J. A., Corey, V., Clarke, D., Derbyshire, E. R., Dornan, G., Duffy, S., Eckley, S., Itoe, M. A., Koolen, K. M. J., Lewis, T. A., Lui, P. S., Lukens, A. K., Lund, E., March, S., Meibalan, E., Meier, B. C., McPhail, J., Mitasev, B., Moss, E. L., Sayes, M., VanGessel, Y., Wawer, M. J., Yoshinaga, T., Zeeman, A. - M., Avery, V. M., Bhatia, S. N., Burke, J. E., Catteruccia, F., Clardy, J. C., Clemons, P. A., Dechering, K. J., Duvall, J. R., Foley, M. A., Gusovsky, F., Kocken, C. H. M., Marti, M., Morningstar, M. L., Munoz, B., Neafsey, D. E., Sharma, A., Winzeler, E. A., Wirth, D. F., Scherer, C. A., and Schreiber, S. L.
Nature (2016)

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Host AMPK Is a Modulator of Plasmodium Liver Infection

M. T. Grilo Ruivo, Vera, I. Medina, Sales-Dias, J., Meireles, P., Gural, N., Bhatia, S. N., Mota, M. M. ‡, and Mancio-Silva, L. ‡
Cell Rep. (2016)

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Comparison of Modular PEG Incorporation Strategies for Stabilization of Peptide–siRNA Nanocomplexes

J. H. Lo†, Kwon, E. J. †, Zhang, A. Q., Singhal, P., and Bhatia, S. N.
Bioconjugate Chemistry (2016)

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Magnetically Actuated Protease Sensors for in Vivo Tumor Profiling

S. Schuerle †, Dudani, J. S. †, Christiansen, M. G., Anikeeva, P. ‡, and Bhatia, S. N. ‡
Nano Letters (2016)

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High-Throughput Platform for Identifying Molecular Factors Involved in Phenotypic Stabilization of Primary Human Hepatocytes In Vitro

J. Shan, Logan, D. J., Root, D. E., Carpenter, A. E., and Bhatia, S. N.
Journal of Biomolecular Screening (2016)

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Synchronized cycles of bacterial lysis for in vivo delivery

O. M. Din†, Danino, T. †, Prindle, A., Skalak, M., Selimkhanov, J., Allen, K., Julio, E., Atolia, E., Tsimring, L. S., Bhatia, S. N. ‡, and Hasty, J. ‡,
Nature (2016)

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